Senior Scientist, Process Development – Biotech – Boston Michael Page Boston, MA

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Job Detail

  • Job ID 122946

Job Description

#Senior #Scientist #Process #Development #Biotech #Boston

Job title:

Senior Scientist, Process Development – Biotech – Boston

Company:

Michael Page

Salary:

$115000 – 135000 per year

Job description

Responsible for the development, optimization, and troubleshooting of upstream and/or downstream processes in support of clinical development of company’s recombinant protein therapeutics. Work in a high collaborative team, providing support to Research and CMC groups.

  • Upstream: Develop scalable mammalian cell culture processes for the production of recombinant therapeutic protein molecules. Screen and optimize process parameters at the shake flask and bench scale bioreactor stages to improve titer and product quality profile. Generate representative protein pools for further downstream development and analytical characterization. Apply statistical analysis and experimental design to evaluate key process parameters. Author process development reports and tech transfer documents to build process knowledge.
  • Downstream: Develop scalable downstream unit operations including chromatography and filtration, as well as robust integrated downstream purification processes. Screen chromatography resins, buffers, and operating parameters. Evaluate and select process filters. Generate representative purified protein as well as in-process fractions or isolates for further analytical characterization. Contribute to process transfers to and from external CMOs through authoring of tech transfer documents, process troubleshooting, or providing technical guidance.
  • Work collaboratively with the internal Research and Discovery group and analytical group to enhance the understanding of company’s pipeline molecules. Plan and execute tasks such as manufacturability assessment, in-process analysis, buffer screening, and product variant/impurity tracking.
  • Plan and maintain laboratory daily functions. Coordinate installation and preventive maintenance of lab equipment. Ensure lab equipment is calibrated and maintained in proper working order. Perform basic equipment troubleshooting and repairs. Maintain a clean and safe working environment.
  • Other duties as may be required.

MPI does not discriminate on the basis of race, color, religion, sex, sexual orientation, gender identity or expression, national origin, age, disability, veteran status, marital status, or based on an individual’s status in any group or class protected by applicable federal, state or local law. MPI encourages applications from minorities, women, the disabled, protected veterans and all other qualified applicants.

Key member of the CMC function for development and production |Join an exciting Publicly traded pre-clinical Biotech in Greater Boston

  • BS/MS (with 5+ years relevant experience) or PhD (with 2+ years experience) in Chemical Engineering, Protein Chemistry, Biochemistry or related fields.
  • Biotech or biopharmaceutical industry experience; experience with start-ups is highly desired.
  • Hands on experience with biopharmaceutical unit operations, including at a minimum:
  • For upstream: mammalian cell culture technique, aseptic technique, measurement of growth, titer, metabolites, seed trains, and stirred-tank bioreactors.
  • For Downstream: Akta Chromatography skids, depth filtration, tangential flow filtration, viral filtration.
  • Additional areas of experience that are considered desirable: familiarity with scale-up and transfer to GMP manufacturing; familiarity with running process analytics, including SDS-page, HPLC/UPLC, ce-SDS, or Elisa; familiarity with current Good Manufacturing Practices (cGMP) for biologics.
  • Excellent communication (both written and verbal), analytical, problem-solving and organizational skills are required.
  • Ability to multitask and adapt prioritization based on project needs.
  • Lab management experience is highly desired.
  • This position primarily involves hands-on laboratory work, involving proximity to chemical or physical hazards, requiring basic safety precautions to be followed.
  • Occasional lifting of laboratory equipment or supplies of up to 40 lbs. is expected.
  • Outside of the lab, work is performed in a typical interior/office environment.

This publicly- traded Boston based company focuses on the development of novel biologic agents targeting the immune system for the treatment of cancer. They are a Pre-Clinical Stage Cell Therapy company that has technology designed to unleash validated and proven pro-inflammatory mechanisms on tumors while preventing unwanted side effects on non-target tissue. They create systemically delivered targeted therapies that address the limitations of immuno-oncology.

  • Competitive base salary
  • Great Health benefits package
  • Competitive PTO policy
  • Stock option program
  • Annual Bonus
  • Fast paced, start up culture

Location

Boston, MA

Job date

Sun, 19 Jun 2022 05:46:41 GMT